Effect of respiratory muscle training in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
Zhongjie Huang,
Zhibin Li,
Meihao Yan,
Jianming Zheng,
Wencheng Huang,
Liyue Hong,
Qiuxiang Lu,
Limin Liu,
Xincheng Huang,
Hongtao Fan,
Weiping Su,
Xiaoping Huang,
Xiaoyan Wu,
Zhixiong Guo,
Caiting Qiu,
Zhaodi Zhao,
Yuancheng Hong
Affiliations
Zhongjie Huang
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Zhibin Li
Department of Emergency Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Meihao Yan
Department of Respiratory Medicine, Jinjiang Hospital, Fujian Hospital Affiliated to Shanghai Sixth People's Hospital, Jinjiang, 362299, China
Jianming Zheng
Department of Infection, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Wencheng Huang
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Liyue Hong
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Qiuxiang Lu
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Limin Liu
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Xincheng Huang
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Hongtao Fan
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Weiping Su
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Xiaoping Huang
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Xiaoyan Wu
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Zhixiong Guo
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Caiting Qiu
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Zhaodi Zhao
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China
Yuancheng Hong
Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, Quanzhou, 362000, China; Corresponding author. Department of Respiratory Medicine, The 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Quanzhou Strait Hospital, No.180 Huayuan Road, Fengze District, Quanzhou, 362000, China.
Objectives: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder characterized by progressive airflow limitation. This meta-analysis aims to evaluate the effectiveness of respiratory muscle training (RMT) on key pulmonary function parameters, inspiratory muscle strength and quality of life in patients with stable COPD. Methods: A comprehensive search was conducted in the databases including PubMed, Cochrane, Web of Science, Embase, and ClinicalTrials.gov, from their inception to June 12, 2023. Randomized controlled trials (RCTs) evaluating the impact of RMT on stable COPD were included for meta-analysis. Results: In total, 12 RCTs involving 453 participants were included in the meta-analysis. RMT demonstrated a significant increase in maximal inspiratory pressure (PImax, MD, 95% CI: 14.34, 8.17 to 20.51, P < 0.001) but not on maximal expiratory pressure (PEmax). No significant improvement was observed in 6-Min walk test (6MWT), dyspnea, forced expiratory volume in 1 s (FEV1), forced vital capacity ratio (FVC) and quality of life between RMT and control groups. However, subgroup analysis revealed a significant negative effect of RMT alone on FEV1/FVC (MD, 95% CI: 2.59, −5.11 to −0.06, P = 0.04). When RMT was combined with other interventions, improvements in FEV1/FVC and FEV1 were found, although not statistically significant. Conclusion: RMT can effectively improve maximal inspiratory pressure in stable COPD patients, but the effect is slight in improving lung function, dyspnea and quality of life. It is recommended to combine with other treatment strategies to comprehensively improve the prognosis of COPD patients.
