Features of vaginal microbiocenosis in prepubertal girls with chronic recurrent vulvovaginitis against the background of concomitant somatic pathology

Abstract

Objectives. To find out the special features of vaginal microbiocenosis in prepubertal girls with chronic recurrent vulvovaginitis against the background of concomitant somatic pathology. Material and methods. The state of microbiocenosis of the vagina was studied in 110 girls with somatic pathology aged 3-6 years with clinical manifestations of exacerbation of chronic vulvovaginitis (main group), divided into three subgroups (I – 38 girls with diseases of the urinary system organs, II – 36 girls with allergic diseases, III – 36 girls with diseases of the gastrointestinal tract and enterobiasis), and in 25 practically healthy girls of the same age without vulvovaginitis (control group). Results. It has been found that the inflammatory type of vaginal microbiocenosis prevailed in girls of subgroups I and II in case of exacerbation of chronic vulvovaginitis according to the microscopy results of vaginal smears. As for girls of subgroup III the inflammatory type of vaginal microbiocenosis and the transitional type occurred with the same frequency. The causative agents of chronic recurrent vulvovaginitis in girls of subgroups I and III are predominantly gram-negative bacteria of the Entobacteriaceae family and Enterococcus spp., at the same time, microbiological disorders are detected simultaneously in two biotopes (urinary tract-vagina; intestine-vagina, respectively) and are characterized by almost the same spectrum of opportunistic microorganisms, but with different frequency of their occurrence. In girls of subgroup II the main pathogen was Staphylococcus aureus. In all examined female patients regardless of somatic pathology there is an associative growth of various opportunistic microorganisms. This fact confirms the polyetiology of the inflammatory process. Conclusions. Further in-depth study of the characteristic properties of vaginal microbiocenosis in prepubertal girls with vulvovaginitis against the background of concomitant somatic pathology is necessary to implement adequate and justified preventive and therapeutic measures.

Keywords

• chronic vulvovaginitis
• prepubertal period
• somatic pathology
• vaginal microbiocenosis