Behavioural Neurology (Jan 2019)

A Repeated Measures Pilot Comparison of Trajectories of Fluctuating Endogenous Hormones in Young Women with Traumatic Brain Injury, Healthy Controls

  • Janet P. Niemeier,
  • Paul B. Perrin,
  • Bradley S. Hurst,
  • David M. Foureau,
  • Toan T. Huynh,
  • Susan L. Evans,
  • Jonathan E. Silverman,
  • M. Elise McClannahan,
  • Benjamin D. Brusch,
  • Mark Newman,
  • Jean-Luc Mougeot,
  • Amy K. Wagner

DOI
https://doi.org/10.1155/2019/7694503
Journal volume & issue
Vol. 2019

Abstract

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Objective. To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting. Hospital emergency department. Participants. 21 women ages 18-35 with TBI and 21 controls. Design. Repeated measures. Main Measures. Serum samples at baseline and 72 hours; immunoassays for estradiol (E2), progesterone (PRO), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and cortisol (CORT); and health history. Results. Women with TBI had lower E2 (p=0.042) and higher CORT (p=0.028) levels over time. Lower Glasgow Coma Scale (GSC) and OCs were associated with lower FSH (GCS p=0.021; OCs p=0.016) and higher CORT (GCS p=0.001; OCs p=0.008). Conclusion. Acute TBI may suppress E2 and increase CORT in young women. OCs appeared to independently affect CORT and FSH responses. Future work is needed with a larger sample to characterize TBI effects on women’s endogenous hormone response to injury and OC use’s effects on post-TBI stress response and gonadal function, as well as secondary injury.