EJC Paediatric Oncology (Jun 2025)
European standard clinical practice recommendations for paediatric high-grade gliomas
- Elwira Szychot,
- Géraldine Giraud,
- Darren Hargrave,
- Dannis van Vuurden,
- Jacques Grill,
- Veronica Biassoni,
- Maura Massimo,
- André O. Von Büren,
- Rejin Kebudi,
- Maria João Gil-da-Costa,
- Sophie Veldhuijzen van Zanten,
- Simon Bailey,
- Michael Karremann,
- Stephanie Bolle,
- Thankamma Ajithkumar,
- Mechthild Krause,
- Yasmin Lassen-Ramshad,
- Geert Janssens,
- Giovanni Morana,
- Ulrike Löbel,
- Shivaram Avula,
- Brigitte Bison,
- Maarten Lequin,
- Kristian Aquilina,
- Ulrich Thomale,
- Pelle Nilsson,
- Sami Bui-Quy Abu Hamdeh,
- Torsten Pietsch,
- Pascale Varlet,
- Thomas S. Jacques,
- Pieter Wesseling,
- David Jones,
- Uri Tabori,
- Anirban Das,
- David Mulligan,
- Francesca Kozmann,
- Christof M. Kramm
Affiliations
- Elwira Szychot
- Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; Pomeranian Medical University, Szczecin, Poland; UCL GOS Institute of Child Health, London, UK; Correspondence to: Department of Paediatric Oncology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, United Kingdom.
- Géraldine Giraud
- Uppsala University, Uppsala, Sweden; Uppsala University Children's Hospital, Uppsala, Sweden
- Darren Hargrave
- Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL GOS Institute of Child Health, London, UK
- Dannis van Vuurden
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
- Jacques Grill
- Institut Gustave Roussy, Villejuif, France
- Veronica Biassoni
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
- Maura Massimo
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
- André O. Von Büren
- University Hospitals of Geneva, Geneva, Switzerland
- Rejin Kebudi
- Istanbul University, Istanbul, Turkey
- Maria João Gil-da-Costa
- Centro Hospitalar Universitário de São João, Porto, Portugal
- Sophie Veldhuijzen van Zanten
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
- Simon Bailey
- Northern Institute for Cancer Research Sir James Spence Institute, Newcastle, UK
- Michael Karremann
- Heidelberg University, Heidelberg, Germany
- Stephanie Bolle
- Institut Gustave Roussy, Villejuif, France
- Thankamma Ajithkumar
- Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
- Mechthild Krause
- Cancer Consortium (DKTK) Dresden, Germany
- Yasmin Lassen-Ramshad
- Aarhus Universitetshospital, Aarhus, Denmark
- Geert Janssens
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
- Giovanni Morana
- Universita degli Studi di Torino, Torino, Italy
- Ulrike Löbel
- Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
- Shivaram Avula
- Alder Hey Children's NHS Foundation Trust, Liverpool, UK
- Brigitte Bison
- Universität Augsburg Medizinische Fakultät, Uugsburg, Germany
- Maarten Lequin
- Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
- Kristian Aquilina
- Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
- Ulrich Thomale
- Charité - Universitätsmedizin Berlin Campus Charite Mitte, Berlin, Germany
- Pelle Nilsson
- Uppsala University, Uppsala, Sweden
- Sami Bui-Quy Abu Hamdeh
- Uppsala University, Uppsala, Sweden
- Torsten Pietsch
- University of Bonn, Bonn, Germany
- Pascale Varlet
- Centre Hospitalier Sainte Anne, Paris, France
- Thomas S. Jacques
- Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL GOS Institute of Child Health, London, UK
- Pieter Wesseling
- Amsterdam Universitair Medische Centra, Amsterdam, Netherlands
- David Jones
- German Cancer Research Centre, Heidelberg, Germany
- Uri Tabori
- Hospital for Sick Children, Toronto, Canada
- Anirban Das
- Hospital for Sick Children, Toronto, Canada
- David Mulligan
- Funding neuro, Glasgow, UK
- Francesca Kozmann
- II Fondo di GIO ONULUS, Trieste, Italy
- Christof M. Kramm
- University of Gottingen, Gottingen, Germany
- Journal volume & issue
-
Vol. 5
p. 100210
Abstract
Paediatric high-grade gliomas (pedHGGs) are highly invasive brain tumours accounting for approximately 15 % of all central nervous system (CNS) tumours in children and adolescents. The outcome for these tumours is generally poor with 5-year survival rates of less than 20 %. Despite improved biological insights into pedHGGs and the promise of more effective therapies, little progress has been made in the effective treatment and the outcome of these tumours over the last four decades. Much of the evidence for the use of chemotherapy in pedHGGs is extrapolated from adult data, and the evidence for its use in the paediatric population is still weak. This guideline was written by members of the SIOPE HGG Working Group as part of the European Standard Clinical Practice (ESCP) Project. The guideline aims to integrate available evidence-based and expert opinion-based information to assist healthcare professionals in the management of pedHGGs and in an attempt to provide equity in healthcare reflecting the varying resources of each European country.
