Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Valerie Barbier; Johanna Erbani; Corrine Fiveash; Julie M. Davies; Joshua Tay; Michael R. Tallack; Jessica Lowe; John L. Magnani; Diwakar R. Pattabiraman; Andrew C. Perkins; Jessica Lisle; John E. J. Rasko; Jean-Pierre Levesque; Ingrid G. Winkler

doi:10.1038/s41467-020-15817-5

Nature Communications (Apr 2020)

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Valerie Barbier,
Johanna Erbani,
Corrine Fiveash,
Julie M. Davies,
Joshua Tay,
Michael R. Tallack,
Jessica Lowe,
John L. Magnani,
Diwakar R. Pattabiraman,
Andrew C. Perkins,
Jessica Lisle,
John E. J. Rasko,
Jean-Pierre Levesque,
Ingrid G. Winkler

Affiliations

Valerie Barbier: Mater Research Institute—The University of Queensland, Translational Research Institute
Johanna Erbani: Mater Research Institute—The University of Queensland, Translational Research Institute
Corrine Fiveash: Mater Research Institute—The University of Queensland, Translational Research Institute
Julie M. Davies: Mater Research Institute—The University of Queensland, Translational Research Institute
Joshua Tay: Mater Research Institute—The University of Queensland, Translational Research Institute
Michael R. Tallack: Mater Research Institute—The University of Queensland, Translational Research Institute
Jessica Lowe: Mater Research Institute—The University of Queensland, Translational Research Institute
John L. Magnani: GlycoMimetics Inc.
Diwakar R. Pattabiraman: Mater Research Institute—The University of Queensland, Translational Research Institute
Andrew C. Perkins: Mater Research Institute—The University of Queensland, Translational Research Institute
Jessica Lisle: Mater Research Institute—The University of Queensland, Translational Research Institute
John E. J. Rasko: Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney
Jean-Pierre Levesque: Mater Research Institute—The University of Queensland, Translational Research Institute
Ingrid G. Winkler: Mater Research Institute—The University of Queensland, Translational Research Institute

DOI: https://doi.org/10.1038/s41467-020-15817-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The cell adhesion molecule E-selectin regulates haematopoietic stem cell self-renewal in the bone marrow vascular niche. Here, the authors show E-selectin adhesion directly induces survival signaling in acute myeloid leukaemia and therapeutic inhibition improves chemotherapy outcomes in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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