A Review: Electrochemical Biosensors for Oral Cancer

Yen-Tzu Lin; Sorour Darvishi; Anant Preet; Tzu-Yen Huang; Sheng-Hsuan Lin; Hubert H. Girault; Ligang Wang; Tzu-En Lin

doi:10.3390/chemosensors8030054

Chemosensors (Jul 2020)

A Review: Electrochemical Biosensors for Oral Cancer

Yen-Tzu Lin,
Sorour Darvishi,
Anant Preet,
Tzu-Yen Huang,
Sheng-Hsuan Lin,
Hubert H. Girault,
Ligang Wang,
Tzu-En Lin

Affiliations

Yen-Tzu Lin: Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan
Sorour Darvishi: École Polytechnique Fédérale de Lausanne (EPFL), Valais Wallis, CH-1950 Sion, Switzerland
Anant Preet: Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan
Tzu-Yen Huang: Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
Sheng-Hsuan Lin: Institute of Data Science and Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan
Hubert H. Girault: École Polytechnique Fédérale de Lausanne (EPFL), Valais Wallis, CH-1950 Sion, Switzerland
Ligang Wang: École Polytechnique Fédérale de Lausanne (EPFL), Valais Wallis, CH-1950 Sion, Switzerland
Tzu-En Lin: Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan

DOI: https://doi.org/10.3390/chemosensors8030054
Journal volume & issue: Vol. 8, no. 3
p. 54

Abstract

Read online

Oral cancer poses a serious threat worldwide owing to its soaring case-fatality rate and its metastatic characteristics of spreading to the other parts of the body. Despite the recent breakthroughs in biomedical sciences, the detection of oral cancer at an early stage is still challenging. Conventional diagnosis in clinics and optical techniques to detect oral cancer in the initial stages are quite complicated as well as not completely accurate. To enhance the survival rate of oral cancer patients, it is important to investigate the novel methodologies that can provide faster, simpler, non-invasive, and yet ultraprecise detection of the onset of oral cancer. In this review, we demonstrate the promising aspects of an electrochemical biosensor as an ideal tool for oral cancer detection. We discuss the cutting-edge methodologies utilizing various electrochemical biosensors targeting the different kinds of biomarkers. In particular, we emphasize on electrochemical biosensors working at the molecular levels, which can be classified into mainly three types: DNA biosensors, RNA biosensors and protein biosensors according to the types of the analytes. Furthermore, we focus on the significant electrochemical methods including cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) to analyze the oral cancer biomarkers (such as IL-6, IL-8, CYFRA 21-1, CD 59 and CIP2A) present in body fluids including saliva and serum, using non-invasive manner. Hence, this review provides essential insights into the development of pioneering electrochemical biosensors for the detection of oral cancer at an early stage.

Published in Chemosensors

ISSN: 2227-9040 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: http://www.mdpi.com/journal/chemosensors

About the journal

Abstract

Keywords