Journal of Pharmacological Sciences (Jan 2017)

Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation

  • Norikazu Kiguchi,
  • Haruka Sakaguchi,
  • Yui Kadowaki,
  • Fumihiro Saika,
  • Yohji Fukazawa,
  • Shinsuke Matsuzaki,
  • Shiroh Kishioka

DOI
https://doi.org/10.1016/j.jphs.2016.11.005
Journal volume & issue
Vol. 133, no. 1
pp. 53 – 56

Abstract

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Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial sciatic nerve (SCN) ligation (PSL) in mice. IL-13 receptor α1 was upregulated in accumulating macrophages in the injured SCN after PSL. Treatment with IL-13 reduced inflammatory macrophage-dominant molecules and increased suppressive macrophage-dominant molecules in cultured lipopolysaccharide-stimulated peritoneal macrophages and ex vivo SCN subjected to PSL. Moreover, the perineural administration of IL-13 relieved tactile allodynia after PSL. These results suggest that IL-13 reverses inflammatory macrophage-dependent neuropathic pain via a phenotype shift toward suppressive macrophages.

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