Antilithiatic effect of Triticum aestivum against sodium oxalate-induced lithiasis in rat model

Abstract

Abstract Background The present study pointed to evaluate the role of Triticum aestivum ethanolic extract (TAEE) in prophylactic and curative regimens on sodium oxalate (NaOx)-prompted lithiasis. Forty-eight rats were divided into the following regimen’s group (24 rats/regimen). Groups I, II, III, and IV served as prophylactic groups and divided as: group I is a vehicle control received 5% DMSO (vehicle). All the remaining groups received NaOx (70 mg/kg b.wt; i.p.). Group II is NaOx lithiatic group, groups III and IV received TAEE and cystone prophylactically at doses of 500 and 750 mg/kg b.wt, respectively, since 1st day to 7th day of lithiasis stimulation. Groups V, VI, VII, and VIII served as curative groups that divided as the prophylactic ones but TAEE and cystone administered from 7th day to 14th day of lithiasis stimulation. Results Lithiatic rats co-/post-treated with TAEE and cystone raised the urinary volume significantly. Also, TAEE showed modulatory effect in inhibiting and curative stone creation. Significant decreases were observed in the calcium and phosphate contents in urine or serum beside the increased magnesium value in lithiatic rats co-/post-treated with TAEE. TAEE significantly ameliorates the kidney function markers, which proposes its antilithiatic role. Moreover, lithiatic rats co-/post-treated with TAEE significantly diminished oxidative injury evoked by NaOx. Conclusions TAEE has antilithiatic role that may be returned to its diuretic and antioxidant activity in addition to its bioactive components including ferulic acid and phytic acid that have the inhibitory properties on crystallization calcium oxalate by lowering the content of stone promotor constituents.

Keywords

• Triticum aestivum ethanolic extract
• Lithiasis
• Calcium oxalate
• Oxidative stress