Frontiers in Immunology (Dec 2021)

SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination

  • Yudi T. Pinilla,
  • Yudi T. Pinilla,
  • Constanze Heinzel,
  • Constanze Heinzel,
  • Lena-Fabienne Caminada,
  • Douglas Consolaro,
  • Douglas Consolaro,
  • Meral Esen,
  • Meral Esen,
  • Meral Esen,
  • Meral Esen,
  • Peter G. Kremsner,
  • Peter G. Kremsner,
  • Peter G. Kremsner,
  • Jana Held,
  • Jana Held,
  • Jana Held,
  • Andrea Kreidenweiss,
  • Andrea Kreidenweiss,
  • Andrea Kreidenweiss,
  • Rolf Fendel,
  • Rolf Fendel,
  • Rolf Fendel

DOI
https://doi.org/10.3389/fimmu.2021.798859
Journal volume & issue
Vol. 12

Abstract

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SARS-CoV-2 antibodies in saliva serve as first line of defense against the virus. They are present in the mucosa, more precisely in saliva, after a recovered infection and also following vaccination. We report here the antibody persistence in plasma and in saliva up to 15 months after mild COVID-19. The IgG antibody response was measured every two months in 72 participants using an established and validated in-house ELISA assay. In addition, the virus inhibitory activity of plasma antibodies was assessed in a surrogate virus neutralization test before and after vaccination. SARS-CoV-2-specific antibody concentrations remained stable in plasma and saliva and the response was strongly boosted after one dose COVID-19 vaccination.

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