Acute Necrotizing Pancreatitis Complicated with Paroxysmal Nocturnal Haemoglobinuria: A Case Report

Abstract

Mengbo Xiao,1 Ying Di,1 Yu An,1 Yunfeng Cui2 1Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin, People’s Republic of ChinaCorrespondence: Yunfeng Cui, Department of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, 6 Changjiang Road, Nankai District, Tianjin, 300100, People’s Republic of China, Tel [phone], Email [email protected]: This report presents a unique case of acute necrotizing pancreatitis(ANP) concomitant with paroxysmal nocturnal hemoglobinuria(PNH), a combination that has not been documented in existing literature. The impact of PNH on ANP and its treatment remains uncertain due to the lack of consensus. The case described herein involves a patient who exhibited both ANP and PNH, subsequently experiencing splanchnic vein thrombosis (SVT), resulting in substantial intra-abdominal and gastrointestinal hemorrhaging. We attempted to analyze the role of PNH in the formation of SVT in ANP and propose some new insights and hypotheses for the treatment of such patients.Keywords: acute necrotizing pancreatitis, paroxysmal nocturnal hemoglobinuria, splanchnic vein thrombosis

Keywords

• acute necrotizing pancreatitis
• paroxysmal nocturnal hemoglobinuria
• splanchnic vein thrombosis