Nature Communications (Aug 2019)
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese
- Ikuyo Kou,
- Nao Otomo,
- Kazuki Takeda,
- Yukihide Momozawa,
- Hsing-Fang Lu,
- Michiaki Kubo,
- Yoichiro Kamatani,
- Yoji Ogura,
- Yohei Takahashi,
- Masahiro Nakajima,
- Shohei Minami,
- Koki Uno,
- Noriaki Kawakami,
- Manabu Ito,
- Ikuho Yonezawa,
- Kei Watanabe,
- Takashi Kaito,
- Haruhisa Yanagida,
- Hiroshi Taneichi,
- Katsumi Harimaya,
- Yuki Taniguchi,
- Hideki Shigematsu,
- Takahiro Iida,
- Satoru Demura,
- Ryo Sugawara,
- Nobuyuki Fujita,
- Mitsuru Yagi,
- Eijiro Okada,
- Naobumi Hosogane,
- Katsuki Kono,
- Masaya Nakamura,
- Kazuhiro Chiba,
- Toshiaki Kotani,
- Tsuyoshi Sakuma,
- Tsutomu Akazawa,
- Teppei Suzuki,
- Kotaro Nishida,
- Kenichiro Kakutani,
- Taichi Tsuji,
- Hideki Sudo,
- Akira Iwata,
- Tatsuya Sato,
- Satoshi Inami,
- Morio Matsumoto,
- Chikashi Terao,
- Kota Watanabe,
- Shiro Ikegawa
Affiliations
- Ikuyo Kou
- Laboratory for Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN
- Nao Otomo
- Laboratory for Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN
- Kazuki Takeda
- Laboratory for Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN
- Yukihide Momozawa
- Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN
- Hsing-Fang Lu
- Laboratory for Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN
- Michiaki Kubo
- Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN
- Yoji Ogura
- Department of Orthopedic Surgery, Keio University School of Medicine
- Yohei Takahashi
- Department of Orthopedic Surgery, Keio University School of Medicine
- Masahiro Nakajima
- Laboratory for Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN
- Shohei Minami
- Department of Orthopedic Surgery, Seirei Sakura Citizen Hospital
- Koki Uno
- Department of Orthopedic Surgery, National Hospital Organization, Kobe Medical Center
- Noriaki Kawakami
- Department of Orthopedic Surgery, Meijo Hospital
- Manabu Ito
- Department of Orthopedic Surgery, National Hospital Organization, Hokkaido Medical Center
- Ikuho Yonezawa
- Department of Orthopedic Surgery, Juntendo University School of Medicine
- Kei Watanabe
- Department of Orthopedic Surgery, Niigata University Medical and Dental General Hospital
- Takashi Kaito
- Department of Orthopedic Surgery, Osaka University Graduate School of Medicine
- Haruhisa Yanagida
- Department of Orthopedic Surgery, Fukuoka Children’s Hospital
- Hiroshi Taneichi
- Department of Orthopedic Surgery, Dokkyo Medical University School of Medicine
- Katsumi Harimaya
- Department of Orthopedic Surgery, Kyushu University Beppu Hospital
- Yuki Taniguchi
- Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo
- Hideki Shigematsu
- Department of Orthopedic Surgery, Nara Medical University
- Takahiro Iida
- Department of Orthopedic Surgery, Dokkyo Medical University Koshigaya Hospital
- Satoru Demura
- Department of Orthopedic Surgery, Kanazawa University Hospital
- Ryo Sugawara
- Department of Orthopedic Surgery, Jichi Medical University
- Nobuyuki Fujita
- Department of Orthopedic Surgery, Keio University School of Medicine
- Mitsuru Yagi
- Department of Orthopedic Surgery, Keio University School of Medicine
- Eijiro Okada
- Department of Orthopedic Surgery, Keio University School of Medicine
- Naobumi Hosogane
- Department of Orthopedic Surgery, Keio University School of Medicine
- Katsuki Kono
- Department of Orthopedic Surgery, Keio University School of Medicine
- Masaya Nakamura
- Department of Orthopedic Surgery, Keio University School of Medicine
- Kazuhiro Chiba
- Department of Orthopedic Surgery, Keio University School of Medicine
- Toshiaki Kotani
- Department of Orthopedic Surgery, Seirei Sakura Citizen Hospital
- Tsuyoshi Sakuma
- Department of Orthopedic Surgery, Seirei Sakura Citizen Hospital
- Tsutomu Akazawa
- Department of Orthopedic Surgery, Seirei Sakura Citizen Hospital
- Teppei Suzuki
- Department of Orthopedic Surgery, National Hospital Organization, Kobe Medical Center
- Kotaro Nishida
- Department of Orthopedic Surgery, Kobe University Graduate School of Medicine
- Kenichiro Kakutani
- Department of Orthopedic Surgery, Kobe University Graduate School of Medicine
- Taichi Tsuji
- Department of Orthopedic Surgery, Meijo Hospital
- Hideki Sudo
- Department of Advanced Medicine for Spine and Spinal Cord Disorders, Hokkaido University Graduate School of Medicine
- Akira Iwata
- Department of Preventive and Therapeutic Research for Metastatic Bone Tumor, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Tatsuya Sato
- Department of Orthopedic Surgery, Juntendo University School of Medicine
- Satoshi Inami
- Department of Orthopedic Surgery, Dokkyo Medical University School of Medicine
- Morio Matsumoto
- Department of Orthopedic Surgery, Keio University School of Medicine
- Chikashi Terao
- Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN
- Kota Watanabe
- Department of Orthopedic Surgery, Keio University School of Medicine
- Shiro Ikegawa
- Laboratory for Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN
- DOI
- https://doi.org/10.1038/s41467-019-11596-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
Adolescent idiopathic scoliosis (AIS) is a common pediatric disease leading to spinal deformities. Here, the authors report GWAS followed by genome-wide meta-analysis in up to 79,211 Japanese individuals, identifying 20 genetic loci for AIS, 14 of which were previously unreported, and perform in vitro validation for rs1978060.
