Communications Biology (Jan 2022)
Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins
- Cliff J. Luke,
- Stephanie Markovina,
- Misty Good,
- Ira E. Wight,
- Brian J. Thomas,
- John M. Linneman,
- Wyatt E. Lanik,
- Olga Koroleva,
- Maggie R. Coffman,
- Mark T. Miedel,
- Qingqing Gong,
- Arlise Andress,
- Marlene Campos Guerrero,
- Songyan Wang,
- LiYun Chen,
- Wandy L. Beatty,
- Kelsey N. Hausmann,
- Frances V. White,
- James A. J. Fitzpatrick,
- Anthony Orvedahl,
- Stephen C. Pak,
- Gary A. Silverman
Affiliations
- Cliff J. Luke
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Stephanie Markovina
- Siteman Cancer Center, and Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Misty Good
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Ira E. Wight
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Brian J. Thomas
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- John M. Linneman
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Wyatt E. Lanik
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Olga Koroleva
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Maggie R. Coffman
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Mark T. Miedel
- Department of Computational and Systems biology, Drug Discovery Institute, University of Pittsburgh
- Qingqing Gong
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Arlise Andress
- Radiation Oncology, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Marlene Campos Guerrero
- Radiation Oncology, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Songyan Wang
- Radiation Oncology, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- LiYun Chen
- Radiation Oncology, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Wandy L. Beatty
- Molecular Microbiology, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Kelsey N. Hausmann
- Molecular Microbiology, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Frances V. White
- Department of Pathology and Immunology, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- James A. J. Fitzpatrick
- Cell Biology and Physiology, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Anthony Orvedahl
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Stephen C. Pak
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- Gary A. Silverman
- Departments of Pediatrics, Washington University School of Medicine and the Children’s Discovery Institute of St. Louis Children’s Hospital
- DOI
- https://doi.org/10.1038/s42003-021-02953-x
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 25
Abstract
Cliff Luke et al. report that lysoptosis is a eukaryotic stand-alone regulated cell death pathway. They identify that this new cell death modality predominates in the absence of neutralizing endogenous inhibitors.
