Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbances

Abstract

The effect of single delta;sleep inducing peptide (DSIP- 60g/kg body weight) administration on the parameters of rat brainmetabolism under the conditions of chronic amphetamine (2.5mg/kg body weight, 21 days) or Madopar-125 in a dose corresponding to 50 mg L;DOPA/kg body weight (30 days) was investigated. The neurotransmitter systems were evaluated based onthe content of biogenic amines, their metabolites, and activity ofneurotransmitter-catabolising enzymes: serotoninergic systemwas characterized by MAO A activity, serotonin (5-OT) and 5-hydroxyindolil acetic acid (5-HIAA) content, and dopaminergic system by MAO B activity, dopamine (DA), noradrenalin(NA), and homovanilliс acid (HVA) content in the cortex andcaudate nucleus of control and experimental rats. The changesin neurotransmitter metabolism parameters induced by DA-activating substances had certain specificity. Characteristics ofthe corrective effect of DSIP under the conditions of amphetamine or L;DOPA action were demonstrated depending on thetype of a pharmacologic agent or brain structures. It is proposedthat DSIP effect in vivo is based on the activation of serotonergic system and normalizes brain metabolism, which leads toadaptive behavior of animals. A possibility of using DSIP, byanalogy with a drug Deltaran, for the treatment of depressions ofvarious origin, cerebral ischemia, etc. is discussed.

Keywords

• delta-sleep inducing peptide
• neurotransmitters
• proteins
• amphetamine
• l-dopa
• brain structures