Conformations and cryo-force spectroscopy of spray-deposited single-strand DNA on gold

Rémy Pawlak; J. G. Vilhena; Antoine Hinaut; Tobias Meier; Thilo Glatzel; Alexis Baratoff; Enrico Gnecco; Rubén Pérez; Ernst Meyer

doi:10.1038/s41467-019-08531-4

Nature Communications (Feb 2019)

Conformations and cryo-force spectroscopy of spray-deposited single-strand DNA on gold

Rémy Pawlak,
J. G. Vilhena,
Antoine Hinaut,
Tobias Meier,
Thilo Glatzel,
Alexis Baratoff,
Enrico Gnecco,
Rubén Pérez,
Ernst Meyer

Affiliations

Rémy Pawlak: Department of Physics, University of Basel
J. G. Vilhena: Department of Physics, University of Basel
Antoine Hinaut: Department of Physics, University of Basel
Tobias Meier: Department of Physics, University of Basel
Thilo Glatzel: Department of Physics, University of Basel
Alexis Baratoff: Department of Physics, University of Basel
Enrico Gnecco: Otto Schott Institute of Materials Research, Friedrich Schiller University Jena
Rubén Pérez: Departamento de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid
Ernst Meyer: Department of Physics, University of Basel

DOI: https://doi.org/10.1038/s41467-019-08531-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 7

Abstract

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Cryo-electron microscopy can determine the structure but not the nanomechanics of biological matter. Here the authors combine force spectroscopy in cryogenic conditions with computer simulations to characterize the properties of DNA simultaneously down to the sub-nm level.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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