PLoS ONE (Jan 2018)

HIV-1 co-receptor tropism and liver fibrosis in HIV-infected patients.

  • Annalisa Saracino,
  • Alessandro Cozzi-Lepri,
  • Milensu Shanyinde,
  • Francesca Ceccherini Silberstein,
  • Silvia Nozza,
  • Antonio Di Biagio,
  • Giovanni Cassola,
  • Giuseppe Bruno,
  • Maria Capobianchi,
  • Massimo Puoti,
  • Laura Monno,
  • Antonella d'Arminio Monforte,
  • ICONA Foundation Study

DOI
https://doi.org/10.1371/journal.pone.0190302
Journal volume & issue
Vol. 13, no. 1
p. e0190302

Abstract

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In vitro, gp120 of both X4 and R5 HIV-1 strains activates human hepatic stellate cells, but if it can promote liver fibrosis in vivo is unknown. We aimed to evaluate if patients carrying X4 or R5 strains have a different liver fibrosis (LF) progression over time.A total of 1,137 HIV-infected patients in ICONA cohort (21% females, 7% HCV co-infected) with an available determination of HIV-1 co-receptor tropism (CRT), a Fibrosis-4 Index for Liver Fibrosis (FIB-4) 100.000 cp/mL, antiretroviral therapy exposure were associated with LF progression at multivariate analysis.A slight LF progression over time was observed in HIV-infected patients. No difference was demonstrated for X4 and R5 HIV-1 strains in accelerating LF evolution.