A case of endometrial intraepithelial neoplasia in a transgender man on testosterone therapy

Reed M. O'Connor; Marla E. Scott; Rania Bakkar; B.J. Rimel

Gynecologic Oncology Reports (Aug 2022)

A case of endometrial intraepithelial neoplasia in a transgender man on testosterone therapy

Reed M. O'Connor,
Marla E. Scott,
Rania Bakkar,
B.J. Rimel

Affiliations

Reed M. O'Connor: Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Marla E. Scott: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Rania Bakkar: Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
B.J. Rimel: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA; Corresponding author at: 8700 Beverly Blvd Ste 290W, Los Angeles, CA 90048, USA.

Journal volume & issue: Vol. 42
p. 101031

Abstract

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Testosterone is commonly used as gender-affirming therapy to induce masculinization in transmasculine individuals. The effects of testosterone therapy on endometrial tissue are complex, and while some patients experience endometrial atrophy while taking testosterone, others do not. Reports of gynecologic malignancies, and endometrial cancer in particular, in transmasculine patients taking testosterone are extremely rare (Urban et al., May 2011; Jeevananthan and Iyengar, 2021; Agnieszka Bobola, 2021). Here we report a case of endometrial intraepithelial neoplasia in a transgender man taking testosterone.

Published in Gynecologic Oncology Reports

ISSN: 2352-5789 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Gynecology and obstetrics; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/gynecologic-oncology-reports/

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Abstract

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