Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins

Haoran Cui; Haoran Cui; Haoran Cui; Yaxian Zhang; Yaxian Zhang; Leiliang Zhang; Leiliang Zhang; Leiliang Zhang

doi:10.3389/fimmu.2021.740223

Frontiers in Immunology (Dec 2021)

Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins

Haoran Cui,
Haoran Cui,
Haoran Cui,
Yaxian Zhang,
Yaxian Zhang,
Leiliang Zhang,
Leiliang Zhang,
Leiliang Zhang

Affiliations

Haoran Cui: Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China
Haoran Cui: Department of Pathogen Biology, School of Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
Haoran Cui: Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Yaxian Zhang: Department of Pathogen Biology, School of Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
Yaxian Zhang: Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Leiliang Zhang: Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China
Leiliang Zhang: Department of Pathogen Biology, School of Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
Leiliang Zhang: Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China

DOI: https://doi.org/10.3389/fimmu.2021.740223
Journal volume & issue: Vol. 12

Abstract

Read online

Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins. Based on their functional domains and ubiquitin transfer mechanisms, these poxvirus-encoded E3 ubiquitin ligases and adaptor proteins can be divided into five categories: PRANC, ANK/BC, BBK, P28/RING, and MARCH proteins. Although the substrates of many poxvirus E3 ubiquitin ligases remain to be discovered, most of the identified substrates are components of the innate immune system. In this review, we discuss the current research progress on poxvirus-encoded E3 ubiquitin ligases and adaptor proteins to provide mechanistic insights into the interplay between these viruses and their hosts.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

About the journal

Abstract

Keywords