Acta Medica Leopoliensia (Dec 2018)
Contribution of different etiology factors in fading pregnancy occurrence
Abstract
Aim. Evaluate the contribution of non-genetic and genetic factors to the occurrence of fading pregnancy at the terms of less / more than 12 weeks of gestation. Material and Methods. The clinical examinations, analysis of genealogical information and laboratory studies, in particular, cytogenetic analysis in 43 couples (86 patients) with history of pregnancy fading were carried out. The spectrum of chromosomal abnormalities in the materials of fading pregnancies was determined using the analysis of medical documentation. Results and Discussion. Fading pregnancy was detected in 79.1% of married couples at the terms of pregnancy <12 weeks. The most common cause of fading pregnancy of not of genetic nature was infectious diseases (TORCH-infection) that found in 44.2% of patients and occupational hazards risk factors was detected in 27.9% persons. Pathology of the genital area was found in 16.3% of patients. In 11.8% of married couples with stopped pregnancy at the term of less than 12 weeks an elevated level of lupus anticoagulant was detected. Eleven point eight percents of I degree relatives of the patients had a history of miscarriage or fading of pregnancies, or infertility more than 10 years. Chromosomal abnormalities were detected in 4.7% of married couples. In 9.5% of married couples was confirmed pericentric inversion of chromosome 9. In the material of fading pregnancies, the predominance of additional copies of autosomes and monosomal chromosome X among chromosomal abnormalities were registered. Chromosomal pathology was detected on a term of pregnancy less than 12 weeks in 32,4% of embryos and on a term of pregnancy more than 12 weeks - in 33,3% of fetus. Conclusion. Investigation of probable risk factors of non-genetic and genetic nature in married couples with fading pregnancy allows predicting possible repeated reproductive losses.
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