A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family

Thomas Hermanns; Christian Pichlo; Ulrich Baumann; Kay Hofmann

doi:10.1038/s41467-022-28049-6

Nature Communications (Jan 2022)

A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family

Thomas Hermanns,
Christian Pichlo,
Ulrich Baumann,
Kay Hofmann

Affiliations

Thomas Hermanns: Institute for Genetics, University of Cologne
Christian Pichlo: Institute of Biochemistry, University of Cologne
Ulrich Baumann: Institute of Biochemistry, University of Cologne
Kay Hofmann: Institute for Genetics, University of Cologne

DOI: https://doi.org/10.1038/s41467-022-28049-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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ZUFSP-type enzymes cleave ubiquitin chains in a linkage-specific fashion, but members from different organisms have different specificities. Using an inter-kingdom comparison of activities and structures, the authors identify the domains responsible for this discrepancy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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