Nature Communications (Feb 2021)

Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging

  • Dorian V. Ziegler,
  • David Vindrieux,
  • Delphine Goehrig,
  • Sara Jaber,
  • Guillaume Collin,
  • Audrey Griveau,
  • Clotilde Wiel,
  • Nadia Bendridi,
  • Sophia Djebali,
  • Valerio Farfariello,
  • Natacha Prevarskaya,
  • Léa Payen,
  • Jacqueline Marvel,
  • Sébastien Aubert,
  • Jean-Michel Flaman,
  • Jennifer Rieusset,
  • Nadine Martin,
  • David Bernard

DOI
https://doi.org/10.1038/s41467-021-20993-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Contacts between mitochondria and endoplasmatic reticulum (ER), and the transfer of calcium between them, have an important role in the regulation of cellular phenotypes, including senescence. Here the authors show that ITPR2 deficient mice display improved aging, associated with a decreased number of contacts between the mitochondria and the ER.