Nature Communications (Feb 2019)

Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo

  • Juliette Fremaux,
  • Claire Venin,
  • Laura Mauran,
  • Robert H. Zimmer,
  • Gilles Guichard,
  • Sébastien R. Goudreau

DOI
https://doi.org/10.1038/s41467-019-08793-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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The peptide hormone GLP-1 has the potential to be a remedy for diabetes type II, yet is unstable. Here, the authors synthesized α-peptide-oligourea hybrid analogues of GLP-1 some of which showing significantly prolonged activity in vivo.