Design and Synthesis of Cysteine Proteases Inhibitors

Abstract

Cysteine proteases belonging to the papain superfamily have been recognized as interesting therapeutic targets for the search for new drugs against infectious tropical diseases such as malaria (falcipain), Chagas’ disease (curtain), leishmaniasis, and Sleeping sickness (rhodesian), and a number of human pathologies, including cancer, Alzheimer’s disease, and osteoporosis (cathepsins). [...]

Keywords

• proteases
• inhibitors
• malaria
• trypanosomiasis
• leishmaniasis