Communications Biology (Jun 2021)

AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division

  • Vasiliki I. Pantazopoulou,
  • Anastasios D. Delis,
  • Stella Georgiou,
  • Stamatis N. Pagakis,
  • Vicky Filippa,
  • Eleni Dragona,
  • Ismini Kloukina,
  • Elias Chatzitheodoridis,
  • Jonel Trebicka,
  • Athanassios D. Velentzas,
  • Maja Thiele,
  • Sarantis Gagos,
  • Dimitris Thanos,
  • Sofia Tseleni-Balafouta,
  • Dimitrios J. Stravopodis,
  • Ema Anastasiadou

DOI
https://doi.org/10.1038/s42003-021-02130-0
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 18

Abstract

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Pantazopoulou et al. find that AGO2 resides in open-ended tunneling nanotubes and close-ended cytokinetic bridges. At the latter location, AGO2 colocalizes with cell division components and the authors show that AGO2 depletion impairs cell division fidelity.