Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials

• Cindy Hoi Ting Yeung,
• Ruud H. J. Verstegen,
• Ruud H. J. Verstegen,
• Rachel Greenberg,
• Rachel Greenberg,
• Tamorah Rae Lewis,
• Tamorah Rae Lewis

Affiliations

Cindy Hoi Ting Yeung

Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada

Ruud H. J. Verstegen

Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada

Ruud H. J. Verstegen

Department of Pediatrics, University of Toronto, Toronto, ON, Canada

Rachel Greenberg

Duke Clinical Research Institute, Durham, NC, United States

Rachel Greenberg

Department of Pediatrics, Duke University School of Medicine, Durham, NC, United States

Tamorah Rae Lewis

Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada

Tamorah Rae Lewis

Department of Pediatrics, University of Toronto, Toronto, ON, Canada