Atg12–Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release

Abstract

We recently identified an interaction between Atg12–Atg3, a complex between 2 core autophagy regulators, and the ESCRT-associated protein Pdcd6ip (programmed cell death 6 interacting protein, commonly known as Alix), which coordinately regulates basal autophagy, late endosome-to-lysosome trafficking, and exosome release. Because these processes all serve fundamental roles in cancer progression and therapy, Atg12-Atg3 may be an attractive anticancer target.

Keywords

• atg12
• atg3
• basal autophagy
• exosome
• late endosome
• pdcd6ip/alix