Comparative Prospective and Longitudinal Analysis on the Platelet-to-Lymphocyte, Neutrophil-to-Lymphocyte, and Albumin-to-Globulin Ratio in Patients with Non-Metastatic and Metastatic Prostate Cancer

Stefano Salciccia; Marco Frisenda; Giulio Bevilacqua; Pietro Viscuso; Paolo Casale; Ettore De Berardinis; Giovanni Battista Di Pierro; Susanna Cattarino; Gloria Giorgino; Davide Rosati; Francesco Del Giudice; Antonio Carbone; Antonio Pastore; Benjamin I. Chung; Michael L. Eisenberg; Riccardo Autorino; Simone Crivellaro; Flavio Forte; Alessandro Sciarra; Gianna Mariotti; Alessandro Gentilucci

doi:10.3390/curroncol29120745

Current Oncology (Dec 2022)

Comparative Prospective and Longitudinal Analysis on the Platelet-to-Lymphocyte, Neutrophil-to-Lymphocyte, and Albumin-to-Globulin Ratio in Patients with Non-Metastatic and Metastatic Prostate Cancer

Stefano Salciccia,
Marco Frisenda,
Giulio Bevilacqua,
Pietro Viscuso,
Paolo Casale,
Ettore De Berardinis,
Giovanni Battista Di Pierro,
Susanna Cattarino,
Gloria Giorgino,
Davide Rosati,
Francesco Del Giudice,
Antonio Carbone,
Antonio Pastore,
Benjamin I. Chung,
Michael L. Eisenberg,
Riccardo Autorino,
Simone Crivellaro,
Flavio Forte,
Alessandro Sciarra,
Gianna Mariotti,
Alessandro Gentilucci

Affiliations

Stefano Salciccia: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Marco Frisenda: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Giulio Bevilacqua: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Pietro Viscuso: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Paolo Casale: Department of Urology, Humanitas, 20089 Milan, Italy
Ettore De Berardinis: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Giovanni Battista Di Pierro: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Susanna Cattarino: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Gloria Giorgino: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Davide Rosati: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Francesco Del Giudice: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Antonio Carbone: Unit of Urology, ICOT Hospital Latina, Sapienza University, 04100 Latina, Italy
Antonio Pastore: Unit of Urology, ICOT Hospital Latina, Sapienza University, 04100 Latina, Italy
Benjamin I. Chung: Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
Michael L. Eisenberg: Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA
Riccardo Autorino: Department of Urology, Rush University Medical Center, Chicago, IL 60612, USA
Simone Crivellaro: Department of Urology, University of Illinois Hospital e Camp, Health Sciences System, Chicago, IL 60612, USA
Flavio Forte: Urology Department, M.G. Vannini Hospital, 00177 Rome, Italy
Alessandro Sciarra: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Gianna Mariotti: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy
Alessandro Gentilucci: Department of “Materno Infantile e Scienze Urologiche, ‘Sapienza’ University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy

DOI: https://doi.org/10.3390/curroncol29120745
Journal volume & issue: Vol. 29, no. 12
pp. 9474 – 9500

Abstract

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Purpose: To prospectively evaluate the albumin/globulin ratio (AGR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) diagnostic and prognostic predictive value in a stratified population of prostate cancer (PC) cases. Methods: Population was divided based on the clinical and histologic diagnosis in: Group A: benign prostatic hyperplasia (BPH) cases (494 cases); Group B: all PC cases (525 cases); Group B1: clinically significant PC (426 cases); Group B2: non-metastatic PC (416 cases); Group B3: metastatic PC (109 cases). NLR, PLR, and AGR were obtained at the time of the diagnosis, and only in cases with PC considered for radical prostatectomy, determinations were also repeated 90 days after surgery. For each ratio, cut-off values were determined by receiver operating characteristics curve (ROC) analysis and fixed at 2.5, 120.0, and 1.4, respectively, for NLR, PLR, and AGR. Results: Accuracy in predictive value for an initial diagnosis of clinically significant PC (csPC) was higher using PLR (0.718) when compared to NLR (0.220) and AGR (0.247), but, despite high sensitivity (0.849), very low specificity (0.256) was present. The risk of csPC significantly increased only according to PLR with an OR = 1.646. The percentage of cases with metastatic PC significantly increased according to high NLR and high PLR. Accuracy was 0.916 and 0.813, respectively, for NLR and PLR cut-off, with higher specificity than sensitivity. The risk of a metastatic disease increased 3.2 times for an NLR > 2.5 and 5.2 times for a PLR > 120 and at the multivariate analysis. Conclusion: PLR and NLR have a significant predictive value towards the development of metastatic disease but not in relation to variations in aggressiveness or T staging inside the non-metastatic PC. Our results suggest an unlikely introduction of these analyses into clinical practice in support of validated PC risk predictors.

Published in Current Oncology

ISSN: 1198-0052 (Print); 1718-7729 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/curroncol

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