Nature Communications (Mar 2023)

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport

  • John T. Canty,
  • Andrew Hensley,
  • Merve Aslan,
  • Amanda Jack,
  • Ahmet Yildiz

DOI
https://doi.org/10.1038/s41467-023-36945-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 15

Abstract

Read online

The mechanisms of microtubule-based mitochondrial transport remain poorly understood. Here, the authors show that the mitochondrial TRAK adaptors activate the dynein-dynactin complex, enhance the motility of kinesin, and can scaffold both motors to control bidirectional transport.