Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate

Abstract

While canonical oxygen-rebound pathway has been utilized by several Fe/2OG enzymes, insights into the desaturation process remain to be elucidated. Here, the authors suggest that a carbocation might be deployed to enable chemically divergent desaturations through decarboxylation and deprotonation.