Gram-Scale Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand

• Raysa Khan,
• Graham Marsh,
• Robert Felix,
• Paul D. Kemmitt,
• Matthias G. J. Baud,
• Alessio Ciulli,
• John Spencer

Affiliations

Raysa Khan

Department of Chemistry, School of Life Sciences, University of Sussex, Brighton, U.K.

Graham Marsh

Tocris Bioscience, Bristol, U.K.

Robert Felix

Tocris Bioscience, Bristol, U.K.

Paul D. Kemmitt

Oncology, AstraZeneca, Cambridge, U.K.

Matthias G. J. Baud

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, U.K.

Alessio Ciulli

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, U.K.

John Spencer

Department of Chemistry, School of Life Sciences, University of Sussex, Brighton, U.K.