Nature Communications (Jun 2019)

The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo

  • Jeshlee Vijayakumar,
  • Charlène Perrois,
  • Marjorie Heim,
  • Luc Bousset,
  • Simon Alberti,
  • Florence Besse

DOI
https://doi.org/10.1038/s41467-019-10554-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The physiological role of prion-like domains (PLDs) within RNA-binding proteins is not well understood. Here, authors show in Drosophila that the PLD in the protein Imp is required for localization of ribonucleoprotein granules to axons and axonal remodelling.