Nature Communications (Feb 2019)

Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane

  • Maria Angela Gomes de Castro,
  • Hanna Wildhagen,
  • Shama Sograte-Idrissi,
  • Christoffer Hitzing,
  • Mascha Binder,
  • Martin Trepel,
  • Niklas Engels,
  • Felipe Opazo

DOI
https://doi.org/10.1038/s41467-019-08677-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Signalling of the B cell receptor (BCR) is pivotal for survival and activation of naïve B cells. Here the authors show, using super-resolution microscopy techniques, that BCRs exist primarily as monomers and dimers in resting B cells, and oligomerize only on stimulation, thereby implicating a function of BCR clustering patterns on B cell biology.