Cardiovascular Pulsatility Increases in Visual Cortex Before Blood Oxygen Level Dependent Response During Stimulus

Niko Huotari; Niko Huotari; Johanna Tuunanen; Johanna Tuunanen; Lauri Raitamaa; Lauri Raitamaa; Ville Raatikainen; Ville Raatikainen; Janne Kananen; Janne Kananen; Heta Helakari; Heta Helakari; Timo Tuovinen; Timo Tuovinen; Matti Järvelä; Matti Järvelä; Vesa Kiviniemi; Vesa Kiviniemi; Vesa Korhonen; Vesa Korhonen

doi:10.3389/fnins.2022.836378

Frontiers in Neuroscience (Feb 2022)

Cardiovascular Pulsatility Increases in Visual Cortex Before Blood Oxygen Level Dependent Response During Stimulus

Niko Huotari,
Niko Huotari,
Johanna Tuunanen,
Johanna Tuunanen,
Lauri Raitamaa,
Lauri Raitamaa,
Ville Raatikainen,
Ville Raatikainen,
Janne Kananen,
Janne Kananen,
Heta Helakari,
Heta Helakari,
Timo Tuovinen,
Timo Tuovinen,
Matti Järvelä,
Matti Järvelä,
Vesa Kiviniemi,
Vesa Kiviniemi,
Vesa Korhonen,
Vesa Korhonen

Affiliations

Niko Huotari: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Niko Huotari: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Johanna Tuunanen: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Johanna Tuunanen: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Lauri Raitamaa: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Lauri Raitamaa: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Ville Raatikainen: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Ville Raatikainen: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Janne Kananen: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Janne Kananen: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Heta Helakari: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Heta Helakari: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Timo Tuovinen: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Timo Tuovinen: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Matti Järvelä: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Matti Järvelä: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Vesa Kiviniemi: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Vesa Kiviniemi: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Vesa Korhonen: Oulu Functional Neuro Imaging Group, Research Unit of Medical Imaging Physics and Technology (MIPT), University of Oulu, Oulu, Finland
Vesa Korhonen: Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland

DOI: https://doi.org/10.3389/fnins.2022.836378
Journal volume & issue: Vol. 16

Abstract

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The physiological pulsations that drive tissue fluid homeostasis are not well characterized during brain activation. Therefore, we used fast magnetic resonance encephalography (MREG) fMRI to measure full band (0–5 Hz) blood oxygen level-dependent (BOLDFB) signals during a dynamic visual task in 23 subjects. This revealed brain activity in the very low frequency (BOLDVLF) as well as in cardiac and respiratory bands. The cardiovascular hemodynamic envelope (CHe) signal correlated significantly with the visual BOLDVLF response, considered as an independent signal source in the V1-V2 visual cortices. The CHe preceded the canonical BOLDVLF response by an average of 1.3 (± 2.2) s. Physiologically, the observed CHe signal could mark increased regional cardiovascular pulsatility following vasodilation.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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