A Comprehensive Review of Silymarin Extraction and Liposomal Encapsulation Techniques for Potential Applications in Food

Abstract

This review explores advances in silymarin extraction and liposomal encapsulation techniques, highlighting their potential applications in the food, pharmaceutical, and cosmetic industries. The study evaluates a range of extraction techniques, including supercritical fluid extraction, microwave-assisted extraction, ultrasound-assisted extraction, and enzyme-assisted extraction, emphasising their efficiency and reduced environmental impact. Furthermore, it examines conventional and innovative liposomal encapsulation techniques, including supercritical carbon dioxide encapsulation and microfluidics, which enhance silymarin’s bioavailability and therapeutic effects. The integration of these methods promises more effective, safe, and eco-friendly silymarin products. This comprehensive review aims to inform readers of the latest research and future industrial applications, with a particular focus on the refinement and scaling up of these processes to meet commercial demands.

Keywords

• silymarin
• liposome technology
• green extraction methods
• supercritical CO₂