mSystems (Oct 2021)
Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure
- Halie M. Rando,
- Adam L. MacLean,
- Alexandra J. Lee,
- Ronan Lordan,
- Sandipan Ray,
- Vikas Bansal,
- Ashwin N. Skelly,
- Elizabeth Sell,
- John J. Dziak,
- Lamonica Shinholster,
- Lucy D’Agostino McGowan,
- Marouen Ben Guebila,
- Nils Wellhausen,
- Sergey Knyazev,
- Simina M. Boca,
- Stephen Capone,
- Yanjun Qi,
- YoSon Park,
- David Mai,
- Yuchen Sun,
- Joel D. Boerckel,
- Christian Brueffer,
- James Brian Byrd,
- Jeremy P. Kamil,
- Jinhui Wang,
- Ryan Velazquez,
- Gregory L. Szeto,
- John P. Barton,
- Rishi Raj Goel,
- Serghei Mangul,
- Tiago Lubiana,
- Anthony Gitter,
- Casey S. Greene
Affiliations
- Halie M. Rando
- ORCiD
- Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Adam L. MacLean
- Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, USA
- Alexandra J. Lee
- Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Ronan Lordan
- ORCiD
- Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Sandipan Ray
- Department of Biotechnology, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, India
- Vikas Bansal
- Biomedical Data Science and Machine Learning Group, German Center for Neurodegenerative Diseases, Tübingen, Germany
- Ashwin N. Skelly
- Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Elizabeth Sell
- Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- John J. Dziak
- Edna Bennett Pierce Prevention Research Center, The Pennsylvania State University, University Park, Pennsylvania, USA
- Lamonica Shinholster
- Mercer University, Macon, Georgia, USA
- Lucy D’Agostino McGowan
- Department of Mathematics and Statistics, Wake Forest University, Winston-Salem, North Carolina, USA
- Marouen Ben Guebila
- Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
- Nils Wellhausen
- Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Sergey Knyazev
- Georgia State University, Atlanta, Georgia, USA
- Simina M. Boca
- Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA
- Stephen Capone
- St. George’s University School of Medicine, St. George’s, Grenada
- Yanjun Qi
- Department of Computer Science, University of Virginia, Charlottesville, Virginia, USA
- YoSon Park
- Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- David Mai
- Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Yuchen Sun
- Department of Computer Science, University of Virginia, Charlottesville, Virginia, USA
- Joel D. Boerckel
- Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Christian Brueffer
- Department of Clinical Sciences, Lund University, Lund, Sweden
- James Brian Byrd
- University of Michigan School of Medicine, Ann Arbor, Michigan, USA
- Jeremy P. Kamil
- ORCiD
- Department of Microbiology and Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA
- Jinhui Wang
- Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Ryan Velazquez
- Azimuth1, McLean, Virginia, USA
- Gregory L. Szeto
- Allen Institute for Immunology, Seattle, Washington, USA
- John P. Barton
- Department of Physics and Astronomy, University of California-Riverside, Riverside, California, USA
- Rishi Raj Goel
- Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Serghei Mangul
- Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California, USA
- Tiago Lubiana
- Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
- Anthony Gitter
- Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA
- Casey S. Greene
- ORCiD
- Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- DOI
- https://doi.org/10.1128/mSystems.00095-21
- Journal volume & issue
-
Vol. 6,
no. 5
Abstract
COVID-19 involves a number of organ systems and can present with a wide range of symptoms. From how the virus infects cells to how it spreads between people, the available research suggests that these patterns are very similar to those seen in the closely related viruses SARS-CoV-1 and possibly Middle East respiratory syndrome-related CoV (MERS-CoV).
