Nature Communications (Jul 2018)

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

  • Roger Badia,
  • Ester Ballana,
  • Marc Castellví,
  • Edurne García-Vidal,
  • Maria Pujantell,
  • Bonaventura Clotet,
  • Julia G. Prado,
  • Jordi Puig,
  • Miguel A. Martínez,
  • Eva Riveira-Muñoz,
  • José A. Esté

DOI
https://doi.org/10.1038/s41467-018-05157-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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CD32 has been previously shown to be expressed preferentially by CD4 T cells latently harbouring HIV-1. Here the authors show that CD32 expression in CD4 T cells is associated with T cell activation, is up-regulated by HIV-1 infection and importantly does not appear to represent an enriched cellular niche for latent HIV-1.