Beilstein Journal of Organic Chemistry (Jul 2013)

Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin

  • Serge Lavoie,
  • Charles Gauthier,
  • Jean Legault,
  • Sylvain Mercier,
  • Vakhtang Mshvildadze,
  • André Pichette

DOI
https://doi.org/10.3762/bjoc.9.150
Journal volume & issue
Vol. 9, no. 1
pp. 1333 – 1339

Abstract

Read online

Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1–3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus. Abiesonic acid (6) exhibited weak cytotoxic activity against A549 (IC50 = 22 µM) while compounds 1 and 4 were weakly active against S. aureus (MIC = 25 µM).

Keywords