Optimal exposure targets for vancomycin in the treatment of neonatal coagulase-negative Staphylococcus infection: A retrospective study based on electronic medical records

Abstract

Background: The currently advocated ratio of area under the curve (AUC) over 24 h to minimum inhibitory concentration (AUC/MIC) > 400 and AUC 280 was a predictor of efficacy (OR: 13.960, 95% CI: 1.891–103.078, P 600 mg h/L was associated with AKI (OR: 9.008, 95% CI: 2.706–29.983, P 400. Conclusion: The optimal exposure targets for vancomycin in neonatal CoNS infection were AUC/MIC > 280 and AUC < 600 mg h/L.

Keywords

• area under the curve
• clinical effect
• nephrotoxicity
• vancomycin