The Relation between Parathyroid Hormone with Some Bone Biochemical Markers in Type II Diabetes Mellitus

Abstract

Background: Diabetes mellitus of type II (T2DM) has a link to bone resorption, as seen by the great level of most osteoclastic activity indicators. As a result, the mineral density of bones is not reduced in individuals with non-insulin-managed T2DM, and this type does not seem to contribute to osteoporosis. This study aims to evaluate the bone metabolism biochemical markers in T2DM patients. Materials and Methods: A total of 120 blood samples were divided into (70) patients (with quite equal numbers of both females and males), and (50) normal cases as controls (also with quite equal numbers of both females and males), the ages were between 30 and 65 years old. During the period between February and August 2020, patients were admitted to Ballad and Salah Aldeen General Hospitals. The samples that were undertaken were (blood sugar, albumin, total calcium, corrected calcium, parathyroid hormone and phosphorus). Results: In male DM patients, there were high significant differences (P≤0.01) in (blood sugar, parathyroid hormone, total calcium, and corrected calcium), but non-significant differences (P≥0.05) in phosphorus. On contrary, in female DM patients, there was high noticeable difference (P≤0.01) in blood sugar, and a considerable difference (P≤0.05) only in albumin, but non-significant differences (P≥0.05) in parathyroid hormone, total calcium, and corrected calcium. Conclusion: The current findings concluded that hyperglycemia combined with an insulin deficiency can result in a hypoparathyriod status with PTH downregulation.

Keywords

• diabetes mellitus (dm)
• bone metabolism
• calcium
• parathyroid hormone