Sorption of Halogenated Anti-Inflammatory Pharmaceuticals from Polluted Aqueous Streams on Activated Carbon: Lifetime Extension of Sorbent Caused by Benzalkonium Chloride Action

Abstract

The enhancement of the adsorption capacity of activated carbon (AC) using benzalkonium chloride (BAC) within the adsorption of halogenated pharmaceuticals flufenamic acid (flufa) and diclofenac (dcf) was investigated in this study. An adsorption kinetic study was performed to evaluate the adsorption mechanisms. The adsorption mechanism of both drugs on granulated AC as well as saturated AC activated by BAC can be evaluated via pseudo-second kinetic order. The equilibrium adsorption capacity of spent granulated AC in co-action with BAC (qflufa = 195.5 mg g−1 and qdcf = 199.5 mg g−1) reached the adsorption capacity of virgin granulated AC (qflufa = 203.9 mg g−1 and qdcf = 200.7 mg g−1). Finally, batch and column arrangements were compared in an effort to possible practical application of exhausted AC in co-action with BAC. In both column and batch experiments, adsorption capacities of spent granulated AC for flufa increased using BAC by 170.4 mg g−1 and 560.4 mg g−1, respectively. The proposed mechanism of adsorption enhancement is the formation of less polar ion pairs and its better affinity to the non-polar AC surface. The drug concentrations were determined using the voltammetric method on carbon paste electrodes. The formation of ion pairs has been studied by the H1 NMR technique, and solubility in water of drugs and respective ion pairs were investigated using octan-1-ol/water coefficients (POW).

Keywords

• adsorption
• activated carbon
• flufenamic acid
• diclofenac
• halogenated pharmaceutical
• carboxylic acid