Сибирский онкологический журнал (Sep 2017)

RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER

  • T. V. Gorodnova,
  • S. B. Baranov,
  • L. N. Shevkunov,
  • S. A. Tyatkov,
  • A. P. Sokolenko,
  • C. B. Kotiv,
  • E. N. Imyanitov,
  • I. V. Berlev

DOI
https://doi.org/10.21294/1814-4861-2017-16-4-103-107
Journal volume & issue
Vol. 16, no. 4
pp. 103 – 107

Abstract

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Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a complete clinical response to radiotherapy in combination with platinum-based chemotherapy. The progression-free survival was 11 months in one case and 8 months in another case.

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