MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

Nourhan Abdelfattah; Subapriya Rajamanickam; Subbarayalu Panneerdoss; Santosh Timilsina; Pooja Yadav; Benjamin C. Onyeagucha; Michael Garcia; Ratna Vadlamudi; Yidong Chen; Andrew Brenner; Peter Houghton; Manjeet K. Rao

doi:10.1038/s41467-018-06808-8

Nature Communications (Oct 2018)

MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

Nourhan Abdelfattah,
Subapriya Rajamanickam,
Subbarayalu Panneerdoss,
Santosh Timilsina,
Pooja Yadav,
Benjamin C. Onyeagucha,
Michael Garcia,
Ratna Vadlamudi,
Yidong Chen,
Andrew Brenner,
Peter Houghton,
Manjeet K. Rao

Affiliations

Nourhan Abdelfattah: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio
Subapriya Rajamanickam: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio
Subbarayalu Panneerdoss: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio
Santosh Timilsina: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio
Pooja Yadav: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio
Benjamin C. Onyeagucha: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio
Michael Garcia: Department of Medicine, University of Texas Health Science Center at San Antonio
Ratna Vadlamudi: Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio
Yidong Chen: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio
Andrew Brenner: Department of Medicine, University of Texas Health Science Center at San Antonio
Peter Houghton: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio
Manjeet K. Rao: Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio

DOI: https://doi.org/10.1038/s41467-018-06808-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 19

Abstract

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The radiation and chemotherapy used for treating medulloblastoma patients cause debilitating side effects. Here, the authors show that miR-584 acts as a therapeutic adjuvant as it sensitizes medulloblastoma to radiation and chemotherapy by targeting HDAC1 or eIF4E3 to enhance spindle defects and DNA damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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