Nature Communications (Oct 2020)
CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury
- Mark J. Ranek,
- Christian Oeing,
- Rebekah Sanchez-Hodge,
- Kristen M. Kokkonen-Simon,
- Danielle Dillard,
- M. Imran Aslam,
- Peter P. Rainer,
- Sumita Mishra,
- Brittany Dunkerly-Eyring,
- Ronald J. Holewinski,
- Cornelia Virus,
- Huaqun Zhang,
- Matthew M. Mannion,
- Vineet Agrawal,
- Virginia Hahn,
- Dong I. Lee,
- Masayuki Sasaki,
- Jennifer E. Van Eyk,
- Monte S. Willis,
- Richard C. Page,
- Jonathan C. Schisler,
- David A. Kass
Affiliations
- Mark J. Ranek
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Christian Oeing
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Rebekah Sanchez-Hodge
- Division of Cardiology, McAllister Heart Institute, The University of North Carolina at Chapel Hill
- Kristen M. Kokkonen-Simon
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Danielle Dillard
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- M. Imran Aslam
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Peter P. Rainer
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Sumita Mishra
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Brittany Dunkerly-Eyring
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Ronald J. Holewinski
- Cedar Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute
- Cornelia Virus
- Division of Cardiology, McAllister Heart Institute, The University of North Carolina at Chapel Hill
- Huaqun Zhang
- Department of Chemistry and Biochemistry, Miami University
- Matthew M. Mannion
- Department of Chemistry and Biochemistry, Miami University
- Vineet Agrawal
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Virginia Hahn
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Dong I. Lee
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Masayuki Sasaki
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- Jennifer E. Van Eyk
- Cedar Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute
- Monte S. Willis
- Division of Cardiology, McAllister Heart Institute, The University of North Carolina at Chapel Hill
- Richard C. Page
- Department of Chemistry and Biochemistry, Miami University
- Jonathan C. Schisler
- Division of Cardiology, McAllister Heart Institute, The University of North Carolina at Chapel Hill
- David A. Kass
- Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions
- DOI
- https://doi.org/10.1038/s41467-020-18980-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Carboxyl terminus of Hsc70-interacting protein (CHIP) is proteostasis regulator. Here the authors show that CHIP-mediated protein turnover is enhanced by PKG-mediated phosphorylation, which results in attenuated cardiac ischemic proteotoxicity.
