Preclinical study the pharmacokinetics of lithium ascorbate

Abstract

We have studied the effects of lithium ascorbate on the Wistar male albino rats using a dose of 1 000 mg/kg. The concentration time curves for whole blood and tissue homogenates of 10 different biological substrates were derived (the brain, the frontal lobe of the brain, heart, aorta, lungs, liver, kidneys, spleen, adrenals, femoral bone). In the framework of the tubeless analysis of the concentrations in whole blood dynamics the following values of pharmacokinetic parameters of lithium ascorbate were obtained: Cmax=50,59 |±g/l, Tmax=1,50 h, Clast=33,7 |±g/l, AUCt=1 750 |±g/l*h, MRTt = 22,9 h, Lz=0,005 1/h, T1/2=141 h, CL = 0,029 l/h, VD=5,9 l. The concentration of lithium in whole blood and in the frontal lobe of the brain remained stable for at least 40...45 hours after the concentration peak. Multicompartment pharmacokinetic analysis showed that the stabilization of the levels of lithium in the blood and in the brain is supported by a special lithium pool, reportedly consisting of adrenal glands, aorta, femur and brain.

Keywords

• аскорбат лития
• бескамерная модель
• многокамерное моделирование
• фармакокинетика
• биосубстрат
• lithium ascorbate
• tubeless model
• multi-compartment model
• pharmacokinetics
• biosubstrate