Coordination Complexes Built from a Ditopic Triazole-Pyrazole Ligand with Antibacterial and Antifungal Performances

Youssef Draoui; Smaail Radi; Mohamed El Massaoudi; Yousra Bahjou; Sabir Ouahhoud; Samira Mamri; Marilena Ferbinteanu; Redouane Benabbes; Mariusz Wolff; Koen Robeyns; Yann Garcia

doi:10.3390/molecules28196801

Molecules (Sep 2023)

Coordination Complexes Built from a Ditopic Triazole-Pyrazole Ligand with Antibacterial and Antifungal Performances

Youssef Draoui,
Smaail Radi,
Mohamed El Massaoudi,
Yousra Bahjou,
Sabir Ouahhoud,
Samira Mamri,
Marilena Ferbinteanu,
Redouane Benabbes,
Mariusz Wolff,
Koen Robeyns,
Yann Garcia

Affiliations

Youssef Draoui: LCAE, Department of Chemistry, Faculty of Science, University Mohamed I, P.O. Box 524, Oujda 60 000, Morocco
Smaail Radi: LCAE, Department of Chemistry, Faculty of Science, University Mohamed I, P.O. Box 524, Oujda 60 000, Morocco
Mohamed El Massaoudi: LCAE, Department of Chemistry, Faculty of Science, University Mohamed I, P.O. Box 524, Oujda 60 000, Morocco
Yousra Bahjou: LCAE, Department of Chemistry, Faculty of Science, University Mohamed I, P.O. Box 524, Oujda 60 000, Morocco
Sabir Ouahhoud: Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Science, University Mohamed I, P.O. Box 524, Oujda 60 000, Morocco
Samira Mamri: Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Science, University Mohamed I, P.O. Box 524, Oujda 60 000, Morocco
Marilena Ferbinteanu: Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, Panduri Road, No. 90, 050663 Bucharest, Romania
Redouane Benabbes: Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Science, University Mohamed I, P.O. Box 524, Oujda 60 000, Morocco
Mariusz Wolff: Institute of Chemical Catalysis, Faculty of Chemistry, Universität Wien, Währinger Straße 38-42, 1090 Wien, Austria
Koen Robeyns: Institute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium
Yann Garcia: Institute of Condensed Matter and Nanosciences, Molecular Chemistry, Materials and Catalysis (IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium

DOI: https://doi.org/10.3390/molecules28196801
Journal volume & issue: Vol. 28, no. 19
p. 6801

Abstract

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Four mononuclear complexes (H3O){[NiL3](ClO4)3} (1), [CoL3](ClO4)2·2H2O (2), [CdL2Cl2] (3) and [CuL3](NO3)2 (4) have been prepared employing a newly synthesized 1,2,4-triazole ligand: 3-(3,5-dimethyl-1H-pyrazol-1-yl)-1H-1,2,4-triazole (L). The structures of the complexes, which crystallized in P63/m (1), P-1 (2), P1 (3), and P21/c (4), are reviewed within the context of the cooperative effect of the hydrogen bonding network and counter anions on the supramolecular formations. Moreover, within the framework of biological activity examination, these compounds showed favorable antibacterial performances compared to those of various species of bacteria, including both Gram-positive and Gram-negative strains. Significant antifungal inhibitory activity towards Fusarium oxysporum f. sp. albedinis fungi was recorded for 3 and 4 over the ligand L.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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