Frontiers in Medicine (May 2022)
Chronic Obstructive Pulmonary Disease With Asthma-Like Features in the General Population in China
- Kewu Huang,
- Kewu Huang,
- Kian Fan Chung,
- Ting Yang,
- Ting Yang,
- Ting Yang,
- Ting Yang,
- Jianying Xu,
- Lan Yang,
- Jianping Zhao,
- Xiangyan Zhang,
- Chunxue Bai,
- Jian Kang,
- Pixin Ran,
- Huahao Shen,
- Fuqiang Wen,
- Yahong Chen,
- Tieying Sun,
- Tieying Sun,
- Guangliang Shan,
- Yingxiang Lin,
- Yingxiang Lin,
- Guodong Xu,
- Sinan Wu,
- Sinan Wu,
- Sinan Wu,
- Ying Wang,
- Ying Wang,
- Xiaoying Gu,
- Xiaoying Gu,
- Xiaoying Gu,
- Xiaoying Gu,
- Ruiying Wang,
- Zhihong Shi,
- Yongjian Xu,
- Xianwei Ye,
- Yuanlin Song,
- Qiuyue Wang,
- Yumin Zhou,
- Wen Li,
- Liren Ding,
- Chun Wan,
- Wanzhen Yao,
- Yanfei Guo,
- Yanfei Guo,
- Fei Xiao,
- Yong Lu,
- Yong Lu,
- Xiaoxia Peng,
- Dan Xiao,
- Dan Xiao,
- Dan Xiao,
- Dan Xiao,
- Dan Xiao,
- Xiaoning Bu,
- Xiaoning Bu,
- Hong Zhang,
- Hong Zhang,
- Xiaolei Zhang,
- Xiaolei Zhang,
- Xiaolei Zhang,
- Xiaolei Zhang,
- Li An,
- Li An,
- Shu Zhang,
- Shu Zhang,
- Zhixin Cao,
- Zhixin Cao,
- Qingyuan Zhan,
- Qingyuan Zhan,
- Qingyuan Zhan,
- Qingyuan Zhan,
- Yuanhua Yang,
- Yuanhua Yang,
- Lirong Liang,
- Lirong Liang,
- Wenjun Wang,
- Wenjun Wang,
- Huaping Dai,
- Huaping Dai,
- Huaping Dai,
- Bin Cao,
- Bin Cao,
- Bin Cao,
- Jiang He,
- Chen Wang,
- Chen Wang,
- Chen Wang,
- Chen Wang,
- Chen Wang,
- Chen Wang,
- Chen Wang,
- Chen Wang
Affiliations
- Kewu Huang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Kewu Huang
- Beijing Institute of Respiratory Medicine, Beijing, China
- Kian Fan Chung
- National Heart & Lung Institute, Imperial College London & Royal Brompton & Harefield NHS Trust, London, United Kingdom
- Ting Yang
- National Center for Respiratory Medicine, Beijing, China
- Ting Yang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Ting Yang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Ting Yang
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Jianying Xu
- Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, China
- Lan Yang
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Jianping Zhao
- 0Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xiangyan Zhang
- 1Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China
- Chunxue Bai
- 2Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
- Jian Kang
- 3Department of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China
- Pixin Ran
- 4State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
- Huahao Shen
- 5Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
- Fuqiang Wen
- 6State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
- Yahong Chen
- 7Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China
- Tieying Sun
- 8Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China
- Tieying Sun
- 9National Center of Gerontology, Beijing Hospital, Beijing, China
- Guangliang Shan
- 0Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, China
- Yingxiang Lin
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Yingxiang Lin
- Beijing Institute of Respiratory Medicine, Beijing, China
- Guodong Xu
- 1Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Sinan Wu
- National Center for Respiratory Medicine, Beijing, China
- Sinan Wu
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Sinan Wu
- 1Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Ying Wang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Ying Wang
- Beijing Institute of Respiratory Medicine, Beijing, China
- Xiaoying Gu
- National Center for Respiratory Medicine, Beijing, China
- Xiaoying Gu
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Xiaoying Gu
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Xiaoying Gu
- 1Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Ruiying Wang
- Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, China
- Zhihong Shi
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- Yongjian Xu
- 0Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xianwei Ye
- 1Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China
- Yuanlin Song
- 2Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
- Qiuyue Wang
- 3Department of Pulmonary and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China
- Yumin Zhou
- 4State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
- Wen Li
- 5Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
- Liren Ding
- 5Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
- Chun Wan
- 6State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
- Wanzhen Yao
- 7Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China
- Yanfei Guo
- 8Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China
- Yanfei Guo
- 9National Center of Gerontology, Beijing Hospital, Beijing, China
- Fei Xiao
- 9National Center of Gerontology, Beijing Hospital, Beijing, China
- Yong Lu
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Yong Lu
- Beijing Institute of Respiratory Medicine, Beijing, China
- Xiaoxia Peng
- 2Center for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
- Dan Xiao
- National Center for Respiratory Medicine, Beijing, China
- Dan Xiao
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Dan Xiao
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Dan Xiao
- 3Tobacco Medicine and Tobacco Cessation Center, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Dan Xiao
- 4WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China
- Xiaoning Bu
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Xiaoning Bu
- Beijing Institute of Respiratory Medicine, Beijing, China
- Hong Zhang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Hong Zhang
- Beijing Institute of Respiratory Medicine, Beijing, China
- Xiaolei Zhang
- National Center for Respiratory Medicine, Beijing, China
- Xiaolei Zhang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Xiaolei Zhang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Xiaolei Zhang
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Li An
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Li An
- Beijing Institute of Respiratory Medicine, Beijing, China
- Shu Zhang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Shu Zhang
- Beijing Institute of Respiratory Medicine, Beijing, China
- Zhixin Cao
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Zhixin Cao
- Beijing Institute of Respiratory Medicine, Beijing, China
- Qingyuan Zhan
- National Center for Respiratory Medicine, Beijing, China
- Qingyuan Zhan
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Qingyuan Zhan
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Qingyuan Zhan
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Yuanhua Yang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Yuanhua Yang
- Beijing Institute of Respiratory Medicine, Beijing, China
- Lirong Liang
- Beijing Institute of Respiratory Medicine, Beijing, China
- Lirong Liang
- 5Department of Epidemiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Wenjun Wang
- Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing, China
- Wenjun Wang
- Beijing Institute of Respiratory Medicine, Beijing, China
- Huaping Dai
- National Center for Respiratory Medicine, Beijing, China
- Huaping Dai
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Huaping Dai
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Bin Cao
- National Center for Respiratory Medicine, Beijing, China
- Bin Cao
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Bin Cao
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Jiang He
- 6Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States
- Chen Wang
- National Center for Respiratory Medicine, Beijing, China
- Chen Wang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Chen Wang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Chen Wang
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Chen Wang
- 3Tobacco Medicine and Tobacco Cessation Center, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Chen Wang
- 4WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China
- Chen Wang
- 7Department of Respiratory Medicine, Capital Medical University, Beijing, China
- Chen Wang
- 8Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- DOI
- https://doi.org/10.3389/fmed.2022.876240
- Journal volume & issue
-
Vol. 9
Abstract
BackgroundPatients with features of both asthma and chronic obstructive pulmonary disease (COPD) are seen commonly in the clinic but less is known in the general population. We investigated the prevalence and the heterogeneity of COPD with concomitant features of asthma in Chinese adult population.MethodsCOPD was defined as post-bronchodilator ratio of forced expiratory volume in 1s (FEV1) to forced vital capacity of less than the lower limits of normal. COPD with concomitant features of asthma was defined as either COPD with asthma diagnosed by self-reported physician-diagnosis or by presence of current wheeze, or as COPD with high bronchodilator response (HBR) defined as an increase in FEV1 >15% and >400 ml after bronchodilator.ResultsCOPD with concomitant features of asthma was found in 1.62% (95% CI 1.31–2.00) of adults (≥20 years) or in 15.2% (95% CI 13.0–17.7) of COPD patients. Compared with COPD with HBR, COPD with asthma diagnosis or wheeze were older (61.8 ± 1.1 years vs. 47.4 ± 2.8 years, P < 0.001), and with a lower post-bronchodilator FEV1%pred (68.2 ± 2.3 vs. 96.6 ± 3.4, P < 0.001). Age, smoking status, biomass use and allergic rhinitis were associated with increasing prevalence of COPD with asthma diagnosis or wheeze, and had greater impaired health status, more comorbidities and more acute exacerbations in the preceding 12 months.ConclusionsCOPD with concomitant features of asthma is common in people with COPD and those with COPD with asthma diagnosis or wheeze experience worse clinical severity than COPD with HBR. These findings will help toward the definition of the asthma-COPD overlap condition.
Keywords
