Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

Abstract

Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on dynein regulators LIS1 and NudE/L, but not on p150glued.