Frontiers in Chemistry (Jun 2021)
Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions
- Yeting Guo,
- Yeting Guo,
- Jianxi Ying,
- Jianxi Ying,
- Dongru Sun,
- Dongru Sun,
- Yumeng Zhang,
- Minyang Zheng,
- Minyang Zheng,
- Ruiwen Ding,
- Ruiwen Ding,
- Yan Liu,
- Yufen Zhao,
- Yufen Zhao,
- Yufen Zhao,
- Yufen Zhao
Affiliations
- Yeting Guo
- Institute of Drug Discovery Technology, Ningbo University, Ningbo, China
- Yeting Guo
- Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, China
- Jianxi Ying
- Institute of Drug Discovery Technology, Ningbo University, Ningbo, China
- Jianxi Ying
- Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, China
- Dongru Sun
- Institute of Drug Discovery Technology, Ningbo University, Ningbo, China
- Dongru Sun
- Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, China
- Yumeng Zhang
- Department of Chemical Biology, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China
- Minyang Zheng
- Institute of Drug Discovery Technology, Ningbo University, Ningbo, China
- Minyang Zheng
- Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, China
- Ruiwen Ding
- Institute of Drug Discovery Technology, Ningbo University, Ningbo, China
- Ruiwen Ding
- Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, China
- Yan Liu
- Department of Chemical Biology, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China
- Yufen Zhao
- Institute of Drug Discovery Technology, Ningbo University, Ningbo, China
- Yufen Zhao
- Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, China
- Yufen Zhao
- Department of Chemical Biology, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China
- Yufen Zhao
- Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
- DOI
- https://doi.org/10.3389/fchem.2021.675821
- Journal volume & issue
-
Vol. 9
Abstract
Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipeptides and whether the reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life.
Keywords
