PFC mTOR signaling as a biological signature for cognitive deficits in bipolar disorder without psychosis

Jelena Radulovic; Vilma Gabbay

Cell Reports Medicine (May 2021)

PFC mTOR signaling as a biological signature for cognitive deficits in bipolar disorder without psychosis

Jelena Radulovic,
Vilma Gabbay

Affiliations

Jelena Radulovic: Albert Einstein College of Medicine, Psychiatry Research Institute at Montefiore Einstein (PRIME), New York, NY, USA; Corresponding author
Vilma Gabbay: Albert Einstein College of Medicine, Psychiatry Research Institute at Montefiore Einstein (PRIME), New York, NY, USA; The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA

Journal volume & issue: Vol. 2, no. 5
p. 100282

Abstract

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Vanderplow et al.1 report decreased PFC Akt-mTOR signaling in males with bipolar disorder (BD) without psychosis compared with those with psychosis, possibly related to cognitive deficits. Understanding how cognition differs between these BD subtypes clinically and biologically remains a challenge.

Published in Cell Reports Medicine

ISSN: 2666-3791 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General)
Website: https://www.cell.com/cell-reports-medicine

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