Nature Communications (Feb 2020)

Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain

  • Louis-Etienne Lorenzo,
  • Antoine G. Godin,
  • Francesco Ferrini,
  • Karine Bachand,
  • Isabel Plasencia-Fernandez,
  • Simon Labrecque,
  • Alexandre A. Girard,
  • Dominic Boudreau,
  • Irenej Kianicka,
  • Martin Gagnon,
  • Nicolas Doyon,
  • Alfredo Ribeiro-da-Silva,
  • Yves De Koninck

DOI
https://doi.org/10.1038/s41467-019-14154-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 23

Abstract

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Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABAA receptor in a neuropathic pain model, inhibition eventually fails due to KCC2 hypofunction.