The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis

Abstract

Host immunity against Candida albicans is crucial in controlling C. albicans infection. The innate immunity is believed to be the first line of host defense, such as the direct killing of yeasts through phagocytosis by neutrophils and macrophages. In addition to innate immune cells, an adjunctive protective effect is played by cellular adaptive immunity represented by Th lymphocytes. The balance of various Th cell subpopulations plays a crucial role in regulating the prognosis of C. albicans infection. Yeasts cell recognition by pattern recognition receptors leads to proinflammatory cytokines synthesis, cause immune system activation and yeast cells killing. However it was demonstrated that C. albicans inhibits immune response which cause infection. Aim - studying vaginal microbiota and the local immune response in women with recurrent vulvovaginal candidiasis for improving the tactics of their management. Results. Our date demonstrates that vaginal disbiosis are risk factor for RVVC and leads to more active innate immune system response.

Keywords

• vulvovaginal candidiasis
• recurrent vulvovaginal candidiasis
• treatment of vulvovaginal candidiasis
• immune response to vulvovaginal candidiasis
• genes expression profile during vulvovaginal candidiasis